M. Florine Démosthène was born in the United States and raised between Port-au-Prince, Haiti, and New York. She earned her Bachelor of Fine Arts from Parsons School of Design and her Master of Fine Arts from Hunter College, City University of New York.

Démosthène has exhibited widely in solo and selected exhibitions across the United States, the Caribbean, the United Kingdom, Europe, and Africa. Recent solo exhibitions include What the Body Carries at the Frist Art Museum, Mastering the Dream at the SCAD Museum of Art, and In the Realm of Love at Mariane Ibrahim Gallery.

Her honors include a Caribbean Cultural Institute-Pérez Art Museum Miami Artist Fellowship, a NYFA Artist Fellowship, an Oklahoma Visual Arts Council Grant, a Project Fellowship with Future Histories Studio at Stony Brook University, the Wachtmeister Award, the Tulsa Artist Fellowship, an Arts Moves Africa Grant, the Black Star Award, and a Joan Mitchell Foundation Grant. She has participated in artist residencies throughout the United States, the Caribbean, the UK, Slovakia, Ghana, and Tanzania.

Her work is held in public and private collections worldwide, including the National Museum of African American History and Culture, the Africa First Collection, the University of South Africa (UNISA), the Lowe Museum of Art, the Hessel Museum of Art, and the PFF Collection of African American Art.